Jared Rutter (U. Utah, HHMI) 1: Mitochondria: The Mysterious Cellular Parasite

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  1. Fascinating stuff, most of it way above my head. But I always find it grates on me when allusions are made to 'evolution' of the complex from the simple. In particular, adding comments about 'this or that evolved to become this or that', contributes ZERO to the revelation of the information, or the marvelous pathways that are unveiled by the meticulous research (which I marvel at). If biological evolutionary theory was worth squat, it would actually provide some kind of insight into why these super complex systems needed to evolve and make it easier to discern what is not yet known about various pathways. What was missing in those primitive organisms that we can now see why the new features evolved? Every organism that ever lived was of necessity, already capable of living, and therefore perfected already, and needed no improvement, by nature. We, as tinkerers can better forecast improvements while looking on from the outside, or at least think we can, because we have already compiled a tree of supposed relationship between all forms of life.

    Instead, the revelation of the information is immediately attributed as some sort of proof of evolution, which makes no more sense than me thinking that my Deja vu is already a Deja vu of another Deja vu. Deja vu explains nothing, it is just a silly notion that explains, forecasts and reveals nothing at all.

    The fact that very smart people have to labor long and hard to retrieve the information for these metabolic pathways makes unguided evolution absolutely ridiculous to contemplate. And if something guided evolution, then we need to know what that something is/was. Maybe. Or maybe we're looking so closely at the trees that we cannot see the forest. Watch some of James Tour's videos to get the gist.

  2. so a third of the proteins of mitochondria aren't understood? 1/3 of those used in the mitochondria or 1/3 of those created by the mitochondrial dna? and about how many is that in a (rough) count? pretty cool tho !!

  3. Selective autophagy pathways, named after the cargo—aggrephagy, mitophagy, xenophagy, and pexophagy—can be ubiquitin (Ub)-dependent and Ub-independent. Four autophagy receptors—p62, NBR1, OPTN, and BNIP3—that can act on one or several pathways were upregulated in APOEε2/c brain samples as common genes for both comparisons, against APOEε3/3 and APOEε4/c(p62 only in APOEε2/c vs APOEε4/c). Numerous upregulated genes involved in the proteasome-mediated Ub-dependent protein catabolic process were significantly upregulated in APOEε2/c brain samples, as well.
    https://www.ncbi.nlm.nih.gov/pubmed/31888770

  4. Slow video, takes over 30 minutes to provide the same rough, inspecific outline of mitochondrial operations, 3 times. This video almost has negative information density, even at 2x speed.

  5. Hi Jared, we did not evolve to be inundated with omega six fatty acids, please pay attention to Chris A. Knobbe, Omega Six Apocalypse, from Cancer, to Heart Disease and macular degeneration. Do pay attention to the leakage in the electron transport chain. https://youtu.be/pHnPinYI2Yc

    On edit to add, PQQ is a supplement that stimulates mitochondrial biogenesis and MitoQ provides stellar protection against excess ROS in mitochondria.

  6. Thanks Dr J.
    What if the answer to either create ATP or Repair is if it’s creating enough/extra ATP?
    What about Ketones?
    Or nutrients needed to optimize the Mito. B Vits? Nad?
    Onto part 2. 👍

  7. I remember in 1977 when I first saw the mitochondria in high school and was fascinated and instinctively knew it was special
    We had to draw the cells in biology classes and I loved it. My most interesting one today is the telomeres and the progress of knowledge of how we age as the telomeres get shorter every time they duplicate

  8. Thank you for sharing your hard earned knowledge! Fantastic overview. I can't wait to listen to the next two sessions.

  9. I love the information! I have always suggested that all college professors take a course in public speaking. Dr. Utter is a fine man and researcher. His presentation skills are lacking. His use of the "uh" pause distracts from the presentation. Toastmasters teaches public speaking.

  10. Great summary, but not interesting depiction. If you want to understand how electron transfer moves protons, hire competent biophysicists. Why didn't you point out that the circular DNA structure is a plasmid?

  11. Given all this dazzling complexity, how do we experience life in such a smooth and seamless way. And just what are we anyway?

  12. Thank you! Fantastic!
    As for mitochondrial communication and feedback loops I think bio photons should play a role. They are emitted in the process of cellular respiration, so it seems logical to play a role. I think that the energy of the photons might break some chemical bonds, so, if their energy is different various chemical reactions might be altered conducting the biochemical pathway to be different.

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